Dr. rer. nat. Janine-Denise Kopicki

Research focus

• native mass spectrometry for the analysis of proteins, protein–protein interactions, and protein–ligand interactions
• quantitative native MS for determining binding affinities
• characterization of MHC–peptide complexes, including identification of potential T-cell epitopes (development of a high-throughput method)
• analysis of antibodies, immunoglobulins, glycoproteins, and diverse proteins from collaboration projects

Methods & approaches

• analysis of protein complexes under native conditions
• quantitative workflows for studying binding and affinity
• native-MS-based screening of MHC–peptide interactions (DE-patent ‘Characterization of MHC-binding peptides using native mass spectrometry’ pending)

Expertise

• native mass spectrometry across different instrument platforms
• analysis of a broad range of immunologically relevant and structurally complex proteins
• co-founder of the DGMS Young Scientist interest group
• postdoctoral representative at the CSSB
• supervision of bachelor’s and master’s students
• teaching experience in seminars, lectures, and laboratory practicals, particularly in biochemistry, bioanalytics, and general chemistry
• SpecDigger_jdk, ein Python-basiertes interaktives Spektrenanalyse-Tool für massenspektrometrische Daten