M.Sc. Jennifer Rothe

Photo of Jennifer Rothe

Function

doctoral candidate in the group of Charlotte Uetrecht

At UzL since

2024

Other affiliations

CSSB Centre for Structural Systems Biology, Deutsches Elektronen-Synchrotron DESY & Leibniz Institute of Virology (LIV) & University of Lübeck, Notkestraße 85, 22607 Hamburg, Germany.
Molecular Biophysics, Zernike Instituut, Rijksuniversiteit Groningen, 9747 AG Groningen, The Netherlands.

Funding

DFG-funded Graduate School RTG2887 „VISualization and imaging of virus infectION“ (VISION)


CSSB Centre for Structural Systems Biology
c/o Deutsches Elektronen-Synchrotron DESY
Notkestraße 85, Building 15
22607 Hamburg
Gebäude CSSB, Raum O2.139

Email: jennifer.rothe(at)uni-luebeck.de
Phone: +49 40 8998 6372
Logo Vision 
Logo © Research Training Group 2887

Research and work

Research focus

  • structural and biophysical characterization of human norovirus-like particles composed of the capsid protein VP1
  • investigation of alternative capsid architectures (T = 1, T = 3, T = 4) arising during VLP production
  • analysis of how N-terminal truncations and targeted point mutations influence capsid assembly, stability, and heterogeneity

Methods & approaches

  • native mass spectrometry and charge-detection MS for determining particle mass, stoichiometry, and assembly states
  • single-particle cryo-electron microscopy for high-resolution visualization of structure, conformational changes, and subunit organization
  • atomic force microscopy for nanoscale analysis of capsid morphology, elasticity, and topology

Expertise

  • atomic force microscopy (AFM)
  • single-particle cryo-EM
  • native MS and charge-detection MS in the megadalton range

CV

2024-present doctoral candidate Rijksuniversiteit Groningen, The Nederlands & University of Lübeck, Institute of Chemistry and Metabolomics, Germany
2023-2024 doctoral candidate Rijksuniversiteit Groningen, The Nederlands & University of Siegen, Germany
2020-2022 master student Hamburg University of Applied Sciences & Forschungszentrum Jülich, Germany
2018-2019 intern Robert Koch Institute, Berlin, Germany
2015-2020 bachelor student Brandenburg University of Technology (BTU) Cottbus-Senftenberg & Leibniz Institute of Virology, Hamburg, Germany