Prof. Dr. Thomas Peters




Gebäude 61, Raum 307a

Email:thomas.peters(at)chemie.uni-luebeck.de
Phone:+49 451 3101-3300
Fax:

Professional employment and academic education

2004 Visiting Professor to the laboratory of Prof. Bundle at the alberta Ingenuity Centre for Carbohydrate Sciences, University of Alberta, Edmonton, Canada
1996-1998 Dean of the Faculty of Natural Sciences, University of Luebeck
Since 1994 Full Professor (C4) and Director of the Institute for Chemistry, University of Luebeck
1992-1994 Privatdozent at the Johann Wolfgang Goethe-University of Frankfurt
1992 Habilitation for "Biophysical Chemistry" at the Johann Wolfgang Goethe-University, Frankfurt am Main
1986-1987 Research Associate at the National Research Council of Canada, Institute of Biological Sciences, Ottawa, in the laboratory of Prof. Dr. D. R. Bundle
1986 Dissertation in the laboratory of Prof. Dr. H. Paulsen, University of Hamburg
1977-1983 Studies of Chemistry at the Universities of Kiel and Hamburg

Honours, distinctions, scholarships, awards

1980-1983 Fellow of the "Studienstiftung des Deutschen Volkes"
1983-1985 Fellow of the "Verband der Chemischen Industrie"
1988-1990 Liebig-Fellow of the "Verband der Chemischen Industrie"
1994 Prize of the "Hermann Wilkomm-Stiftung"
2004 Roy L. Whistler Award of the "International Carbohydrate Organization"

Editorial and advisory boards

Since 2006 Member of the Editorial Board of the "Journal of Carbohydrate Chemistry"
2006-2012 Member of the Editorial Board of "Carbohydrate Research"
Since 2008 Member of the Editorial Board of "Glycoconjugate Journal"
Since 2008 Member of the Advisory Committee for the Resource for Integrated Glycotechnology, Complex Carbohydrate Research Centre, University of Athens, GA, USA

Research topics

NMR studies of protein-carbohydrate interactions (monoclonal antibodies, lectins, selectins, siglecs, glycosyltransferases).
NMR studies of the glycosylation of cells, cellular fragments and glycoproteins; NMR studies of ligand binding to native viruses and viral coat proteins, design of novel entry inhibitors.
Recombinant production of isotope labeled glycosyltransferases for NMR spectroscopy experiments.
Studies of thermodynamic and kinetic aspects of carbohydrate-proteion recognition reactions using NMR, surface plasmon resonance, and isothermal titration calorimetry.

Ten most important publications (Hirsch-Index 30, Researcher ID F-6335-2011)

  1. Mallagaray, A., Lockhauserbäumer, J., Hansman, G.S., Uetrecht, C. and Peters, T. (2015) Attachment of Norovirus to Histo Blood Group Antigens: A Cooperative Multistep Process. Angew Chem Int Ed54, 12014-12019.
  2. Fiege, B., Rademacher, C., Cartmell, J., Kitov, P.I., Parra, F. and Peters, T. (2012) Molecular Details of the Recognition of Blood Group Antigens by a Human Norovirus as Determined by STD NMR Spectroscopy. Angew Chem Int Ed Engl51, 928-932.
  3. Rademacher, C., Guiard, J., Kitov, P.I., Fiege, B., Dalton, K.P., Parra, F., Bundle, D.R. and Peters, T. (2011) Targeting norovirus infection-multivalent entry inhibitor design based on NMR experiments. Chemistry17, 7442-7453.
  4. Zakhour, M., Ruvoen-Clouet, N., Charpilienne, A., Langpap, B., Poncet, D., Peters, T., Bovin, N. and Le Pendu, J. (2009) The aGal Epitope of the Histo-Blood Group Antigen Family Is a Ligand for Bovine Norovirus Newbury2 Expected to Prevent Cross-Species Transmission. PLoS Pathog5, e1000504.
  5.  Rademacher, C., Krishna, N.R., Palcic, M., Parra, F. and Peters, T. (2008) NMR experiments reveal the molecular basis of receptor recognition by a calicivirus. J Am Chem Soc130, 3669-3675.
  6.  Munch, J., Standker, L., Adermann, K., Schulz, A., Schindler, M., Chinnadurai, R., Pohlmann, S., Chaipan, C., Biet, T., Peters, T. et al. (2007) Discovery and Optimization of a Natural HIV-1 Entry Inhibitor Targeting the gp41 Fusion Peptide. Cell129, 263-275.
  7. Meyer, B. and Peters, T. (2003) NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors. Angew Chem Int Ed Engl42, 864-890.
  8. Benie, A.J., Moser, R., Bauml, E., Blaas, D. and Peters, T. (2003) Virus-ligand interactions: identification and characterization of ligand binding by NMR spectroscopy. J Am Chem Soc125, 14-15.
  9. Vogtherr, M. and Peters, T. (2000) Application of NMR based binding assays to identify key hydroxy groups for intermolecular recognition. J. Am. Chem. Soc.122, 6093-6099.
  10. Meyer, B., Weimar, T. and Peters, T. (1997) Screening mixtures for biological activity by NMR. Eur J Biochem246, 705-709.

Patents

Peters, T. and Meyer, B. , Detecting Biologically Active Compounds from Compound Libraries, US-Pat. No. US6214561
Peters, T. and Meyer, B. , Detecting Biologically Active Compounds from Compound Libraries, GB-Pat. No. GB2321104
Peters, T. and Meyer, B., Verfahren zum Nachweis biologisch aktiver Substanzen in Substanzbibliotheken, German Patent No. DE19649359
Peters, T. and Meyer, B., Verfahren zum Nachweis biologisch aktiver Substanzen in Substanzbibliotheken, Swiss Patent No. CH690695